Interested in unraveling the complexity of the bone marrow microenvironment in hematological diseases and metastasis and/or develop cutting-edge single-cell technologies?
We are seeking two motivated doctoral student to join our „Quantitative Spatial Cancer Biology" research group at the Dr. Senckenberg Institute of Pathology and the Mildred Scheel Career Center (MSNZ) Frankfurt, an excellence program supporting careers in translational cancer research (funded by the German Cancer Aid). The lab, headed by Dr. Konstantinos Kokkaliaris, specializes in hematopoietic stem-cell biology and bone marrow tissue organization in health and cancer. We use innovate single-cell protein profiling technologies including cutting-edge multiplexed tissue imaging, multicolor flow cytometry and mass cytometry. The focus of the lab is to profile complex 3D tissue organization, uncover cell-cell interactions in homeostasis, cancer and aging and further develop multiplex tissue imaging modalities.
The projects aim at defining the key cellular, molecular and structural alterations in bone marrow tissue in hematologic diseases and bone metastasis. We will focus on targetable interactions between disease-initiating cells, healthy hematopoietic stem cells and their tissue microenvironment(s). Our goal is to leverage those findings towards the design of novel therapeutic intervention strategies to prolong disease-free survival while supporting healthy tissue function.
Do you have?
- Master’s degree in life sciences or equivalent
- Passion for discovery, collaborative spirit & good communication skills
- Basic experience in laboratory techniques (i.e. molecular biology)
- Previous experience on the biology of hematologic diseases or metastasis is a strong plus
- Good knowledge of English
- Training on cutting-edge single-cell technologies and access to world-class research infrastructure on campus